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By Privatdozentin Dr. med. Ursula Creutzig (auth.), Privatdozentin Dr. med. Ursula Creutzig, Professor Dr. med. Jörg Ritter, Professor Dr. med. Günther Schellong (eds.)

ISBN-10: 3540520708

ISBN-13: 9783540520702

ISBN-10: 3642753515

ISBN-13: 9783642753510

The result of remedy for formative years acute myelogenous leukemia (AML) have more desirable significantly over the past ten years. This growth used to be verified through the 2 consecutive multicenter reviews, AML-BFM-78 and -83, within which virtually exact prolonged multi drug regimes of che­ motherapy have been administered for 8 weeks and up through years upkeep. the most distinction within the moment research was once the addition of an eight-day extensive in­ duction direction. because of this new point, the relapse expense was once diminished considerably. one other results of the BFM-83 examine was once the definition of 2 threat teams at the foundation of standardized therapy, which has result in a risk-adapted remedy technique within the 3rd ongoing trial, AML-BFM- 87. This development used to be in simple terms attainable because of the coop­ eration of pediatricians, physicians, radiotherapists, statisti­ cians, and particularly the employees on the hospitals and reference laboratories. hence, we want to thank everybody who has been all for those stories and wish that they're going to be additional inspired to enhance therapy innovations for AML in teenagers. The coordination, enforcement, and analyses of the stud­ ies don't have been attainable with out the monetary sup­ port of the Federal Ministry for study and expertise of the FRG. we're thankful for the beneficiant contributions aiding this booklet from Lederle and Farmitalia. Munster, April 1990 Ursula Creutzig Jorg Ritter Gunther Schellong Contents 1 creation . . . . .. . . . . . . . . . . . . . . .. . . . 1 .

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Extra info for Acute Myelogenous Leukemia in Childhood: Implications of Therapy Studies for Future Risk-Adapted Treatment Strategies

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AML-83 6 N = 119 N - 134 8 113 12 14 16 18 AGE [YEARS] Fig. 5b). All other morphologic, immunologic, cytogenetic, and flow cytophotometric findings are discussed in detail in the following section. Table 7. Extramedullary organ involvement in studies AML-BFM-78 and AMLBFM-83 AML-BFM-78 No. gingiva Lymphoma Intestines Muscular system Pericard Lungs Testes Testes and skin All organs Kidney Bone Orbita AML-BFM-83 8 4 3 1 3 2 4 1 13 7 4 2 2 2 2 1 t 1 1 2 to} ! 3 0 .... Il! 0 n. 0 Il! n. 0+---~--~--~--~~--L---4----L--~6 100 a 1000 TOTAL GROUP 10000 (N = 333 ) 100000 1·10, LEUKOCYTES Fig.

3b, c and 4b, c). The differences in age distribution between the total groups of the two studies may be attributed to the higher p'roportion of patients with FAB M5 in study AML-BFM-83 (26% vs. 21%, see Table 8). When these patients are excluded, the difference in median age between the two studies is reduced (AML-BFM-78: 10;3 years; AML-BFM-83: 9;3 years). The cumulative frequency curve of the age distribution shows a steady slope after exclusion of the FAB M5 patients (Fig. 3 o H I- ~ D. ~ D.

A Probability of EFS duration in patients with FAB Ml in AML-BFM-78 vs. AML-BFM-83. b Same for EFI duration FAB M3. Out of a total of 11 patients with acute promyelocytic leuke- mia, two suffered ED from intracranial hemorrhage, one from ulcer bleeding and one from sepsis. Of the two children who died in CCR, one died after six weeks from the sequelae of anthracycline-induced cardiotoxicity, the other from undetected tuberculosis after eight months. There was only one relapse after six months. Four patients remained in CCR, for 39, 54, 92, and 116 months respectively (Table 19).

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Acute Myelogenous Leukemia in Childhood: Implications of Therapy Studies for Future Risk-Adapted Treatment Strategies by Privatdozentin Dr. med. Ursula Creutzig (auth.), Privatdozentin Dr. med. Ursula Creutzig, Professor Dr. med. Jörg Ritter, Professor Dr. med. Günther Schellong (eds.)


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